The predictive value of inflammatory biomarkers in the detection of multiple sclerosis attacks

Multiple sclerosis (MS) is the most prevalent immune-mediated inflammatory demyelinating central nervous system disorder, with a diverse set of clinical signs and symptoms. This study aimed to investigate diagnostic values monocyte/lymphocyte ratio (MLR), red cell distribution width/lymphocyte (RLR), systemic immune-inflammation index (SII) in detecting multiple attacks patients Relapsing-remitting MS (RRMS) presenting emergency department (ED). retrospective observational was conducted among RRMS ED third-level hospital. The laboratory parameters 165 were compared during attack non-attack periods. paired t-test statistic used compare means biomarker measurements between groups. neutrophil/lymphocyte (NLR), MLR, RLR, SII mean periods higher than those period. difference NLR, both groups 5.40±7.25, 0.37±0.43, 7.77±11.61, 1469.19±1978.88, respectively (p<0.001). In ROC analysis, had excellent power relapse (AUC: 0.87, 0.81, 0.86, respectively). According our findings, SII, RLR may be beneficial confirming diagnosis RRMS.